Endocrine Abstracts

Introduction: At the onset of type 1 diabetes mellitus (T1DM), children often experience a partial remission which is characterized by decreased insulin requirements. Usually, some exogenous insulin is still needed during this honeymoon phase. We present cases of 2 children with T1DM who had significantly extended periods where no exogenous insulin was required. Case 1: 12-year-old girl presented with fatigue and weight gain. HbA1c in primary care was 51 mmol/mol. BMI was +3 <...

Introduction: Diabetes teams need to keep electronic data records for supporting participation in the National Paediatric Diabetes Audit (NPDA), and other governance activities. NPDA benchmarks diabetes services against each other, and services are keen to make sure their data is accurate so that it gives a good reflection of their service. Twinkle is a specialised database that is widely used for this purpose.Twinkle allows units to produce specific rep...

Congenital hypogonadotropic hypogonadism (CHH) is a pathological condition characterised by lack of pubertal onset and must be differentiated from self-limited delayed puberty (SLDP). There is a significant overlap between these two conditions both in clinical and biochemical features, with current diagnostic approaches lacking sensitivity. Thus, paediatric endocrine clinicians are faced with difficulty in ascertaining the correct diagnosis in adolescence. The presence of cert...

Late diagnosis of type 1 diabetes, leading to diabetic ketoacidosis (DKA) is a significant concern in the UK. The National Paediatric Diabetes Audit 2021/22 showed that 25.6% of children and young people diagnosed with type 1 diabetes in England and Wales presented in DKA, with a rising trend over recent years. Reduction in DKA at diagnosis is part of Aim 1 of the National Children & Young People’s Diabetes Network (NCYPDN) Delivery Plan 2020–25. A working group ...